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99234.9 public utilities code2/16/2023 Whether the combined effects of multiple previously reported genetic loci together with lifestyle factors can improve the prediction of RA risk remains unclear.īased on previously reported results and a large-scale Biobank dataset, we constructed a polygenic risk score (PRS) for RA to evaluate the combined effects of the previously identified genetic loci in both case-control and prospective cohorts. Effective identification of high-risk rheumatoid arthritis (RA) individuals is still a challenge.
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